fentanyl

noun

fen·​ta·​nyl ˈfen-tə-ˌnil How to pronounce fentanyl (audio)
nonstandard -ˌnȯl
: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally (as by intravenous or epidural injection)

Examples of fentanyl in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
In addition to fentanyl, toxicology tests detected alprazolam, commonly known as Xanax; the muscle relaxant methocarbamol; and quetiapine, a medication primarily used to treat schizophrenia, bipolar disorder, and, in some cases, depression. — Nancy Dillon, Rolling Stone, 8 Oct. 2026 Seizures included guns, cash, vehicles, along with methamphetamine and fentanyl. — Julie Sharp, CBS News, 8 Oct. 2026 In separate bodycam footage obtained by TMZ, Giudice can be heard telling police that Milania had fentanyl in her system from a previous incident, prompting Milania to claim she’d been laced. — Jessica Schladebeck, New York Daily News, 8 Oct. 2026 The investigation into Panettiere's death remains ongoing, with the focus likely shifting to the source of the fentanyl. — ABC News, 7 Oct. 2026 See All Example Sentences for fentanyl

Word History

Etymology

probably alteration of phenethyl, a monovalent radical derived from ethylbenzine, from phen- + ethyl

First Known Use

1964, in the meaning defined above

Time Traveler
The first known use of fentanyl was in 1964

Browse Nearby Words

Cite this Entry

“Fentanyl.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/fentanyl. Accessed 9 Oct. 2026.

Medical Definition

: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally

Note: Fentanyl is marketed under the trademark Actiq.

More from Merriam-Webster on fentanyl

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!