liver

1 of 2

noun (1)

liv·​er ˈli-vər 

1

a

: a large very vascular glandular organ of vertebrates that secretes bile and causes important changes in many of the substances contained in the blood (as by converting sugars into glycogen which it stores up until required and by forming urea)

b

: any of various large compound glands associated with the digestive tract of invertebrate animals and probably concerned with the secretion of digestive enzymes

2

archaic : a determinant of the quality or temper of a human being

3

: the liver of an animal (such as a calf or chicken) eaten as food

4

: a grayish reddish brown

called also liver brown, liver maroon

liver

2 of 2

noun (2)

liv·​er ˈli-vər 

1

: one that lives especially in a specified way

a fast liver

2

: resident

Examples of liver in a Sentence

Recent Examples on the Web

Noun

In the livers of urban fish, 425 genes in juveniles and 585 in adults showed activity largely linked to inflammation and immune system responses that was not seen in damselfish living in clean, untouched reef areas. — New Atlas, 9 Oct. 2026

While some people can clear the infection on their own, the majority are at major risk of developing chronic, potentially fatal conditions like cirrhosis and end-stage liver disease. — Philip A. Chan, STAT, 8 Oct. 2026

John had become seriously ill with a liver disease, and the couple had relocated to Koh Samui to seek out a special herb that grew here. — Condé Nast, Condé Nast Traveler, 8 Oct. 2026

In both mice and people who trained, stopped, then trained again, their livers released higher levels of a family of enzymes called carboxylesterases. — Diego Hernandez-Saavedra, The Conversation, 7 Oct. 2026

Word History

Etymology

Noun (1)

Middle English, from Old English lifer; akin to Old High German lebra liver

First Known Use

Noun (1)

before the 12th century, in the meaning defined at sense 1a

Noun (2)

14th century, in the meaning defined at sense 1

Phrases Containing liver

• chopped liver
• cod-liver oil
• liver fluke
• liver pudding
• liver sausage
• liver spots

Rhymes for liver

• giver
• livre
• quiver
• river
• shiver
• sliver
• caregiver
• deliver
• downriver
• lawgiver
• upriver

Kids Definition

liver

1 of 2 noun

liv·​er ˈliv-ər 

1

a

: a large glandular organ of vertebrates that secretes bile and causes changes in the blood (as by changing sugars into glycogen and by forming urea)

b

: any of various large probably digestive glands of invertebrate animals

2

: the liver of an animal (as of a calf or chicken) eaten as food

liver

2 of 2 noun

liv·​er ˈliv-ər 

: one that lives especially in a specified way

Medical Definition

liver

noun

liv·​er ˈliv-ər 

1

a

: a large very vascular glandular organ of vertebrates that secretes bile and causes important changes in many of the substances contained in the blood which passes through it (as by converting sugars into glycogen which it stores up until required and by forming urea), that in humans is the largest gland in the body, weighs from 40 to 60 ounces (1100 to 1700 grams), is a dark red color, and occupies the upper right portion of the abdominal cavity immediately below the diaphragm, that is divided by fissures into five lobes, and that receives blood both from the hepatic artery and the portal vein and returns it to the systemic circulation by the hepatic veins

b

: any of various large compound glands associated with the digestive tract of invertebrate animals and probably concerned with the secretion of digestive enzymes

2

: the liver of an animal (as a calf or pig) eaten as food or used as a source of pharmaceutical products (as liver extract)

3

: disease or disorder of the liver : biliousness